Doctor’s Formulas D-Mannose For Normal Urinary Function 30 capsules

Formula D – Mannose is a dietary supplement containing the monosaccharide D-mannose and blackcurrant extract. Gooseberry contributes to the normal functioning of the urinary system and bladder.

What is D-Mannose?
D-mannose is a simple sugar, which has a special contribution to metabolism, through its role in the glycosylation of certain proteins. D-mannose is rapidly absorbed and reaches the peripheral organs in about 30 minutes and is then excreted by the urinary system. It cannot be converted into glycogen, therefore, it is not stored in the body. It adheres to lectins and thus prevents the attachment of pathogenic organisms to the walls of the bladder.

Action mechanism
Its mechanism of action is expressed through inhibition of adhesion of the surface protein FimH. By direct binding of FimH to D-mannose bound to a carrier protein, which is responsible for receptor specificity.

The 1st adhesion step involves the mannose-sensitive binding of FimH to the epithelium. The bladder wall is coated with various mannose-glycosylated proteins, such as the Tamm-Horsfall protein (THP) that directly interferes with the adhesion of microbes to the mucosa. Tamm-Horsfall protein (THP) can bind to E. Coli with a specific bond, which can be inhibited by exogenous D-mannose.

By inhibiting the adhesion of microbes to the epithelium of the urinary tract, D-mannose mimics the function of the epithelial barrier of the urinary tract.

Without preservatives, gluten, fragrances, sweeteners.

Take 1-2 capsules per day.